Related Areas
April 2003 Ask-the-Expert Conference: Aromatase Inhibitors
http://www.breastcancer.org/cmty_trans_2003_04.html
Sept. 2002 Ask-the-Expert Conference: Alternatives to Tamoxifen
http://www.breastcancer.org/cmty_trans_2002_09_19.html
Another approach to anti-estrogen therapy is to lower the amount of
estrogen
being produced by the body. This method contrasts with that of SERMs or
ERDs, which block estrogen?s ability to "turn on" cancer cells. Limiting
the
amount of estrogen produced means there is less estrogen available to
reach
cancer cells and make them grow.
In post-menopausal women, estrogen is no longer produced by the ovaries,
but
is converted from androgen, another hormone. Aromatase inhibitors keep
androgen from being converted to estrogen. That means less estrogen in
the
bloodstream, and less estrogen reaching estrogen receptors to trigger
trouble.
Arimidex (chemical name: anastrozole), Femara (chemical name: letrozole),
and Aromasin (chemical name: exemestane) are the aromatase inhibitors in
current use, primarily for post-menopausal women with metastatic breast
cancer (cancer that has spread beyond the breast). Each is taken in pill
form.
In the past, these medications were most commonly used by women who may
have
already tried other anti-estrogen therapies, such as tamoxifen, and whose
cancer was no longer controlled by those drugs. Now with the results of
new
studies, many doctors
http://www.breastcancer.org/tre_sys_hrt_serd.html
http://www.breastcancer.org/tre_sys_hrt_serm.html
http://www.breastcancer.org/tre_sys_hrt_newOpt.html
http://www.breastcancer.org/tre_sys_hrt_role.html
http://www.breastcancer.org/research_hormonal_abst3.html
http://www.breastcancer.org/research_hormonal_abst1.html
http://www.breastcancer.org/research_hormonal_abst129.html
http://www.breastcancer.org/letrozole_femara.html
http://www.breastcancer.org/research_hormonal_celebrex.html
http://www.breastcancer.org/research_hormonal_asco2003a.html
http://www.breastcancer.org/research_hormonal_120002b.html Zometa
http://www.breastcancer.org/research_hormonal_050503a.html memory
http://www.breastcancer.org/research_hormonal_050002.html Neurontin for
hot
flashes
http://www.breastcancer.org/research_hormonal_000002.html
http://www.breastcancer.org/tre_sys_hrt_erds.html